Estimating the persistence length of a worm-like chain molecule from force-extension measurements

被引：549

作者：

Bouchiat, C

Wang, MD

Allemand, JF

Strick, T

Block, SM

Croquette, V

机构：

[1] CNRS, Lab Propre, ENS, LPT, Paris, France

[2] Cornell Univ, Dept Phys, LASSP, Ithaca, NY 14853 USA

[3] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[4] Univ Paris 06, URA D 1306 CNRS, ENS, LPS, F-75231 Paris, France

[5] Univ Paris 07, URA D 1306 CNRS, ENS, LPS, F-75231 Paris, France

来源：

BIOPHYSICAL JOURNAL | 1999年 / 76卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0006-3495(99)77207-3

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

We describe a simple computation of the worm-like chain model and obtain the corresponding force-versus-extension curve. We propose an improvement to the Marko and Siggia interpolation formula of Bustamante et al (Science 1994, 265:1599-1600) that is useful for fitting experimental data. We apply it to the experimental elasticity curve of single DNA molecules. Finally, we present a tool to study the agreement between the worm-like chain model and experiments.

引用

页码：409 / 413

页数：5

共 18 条

[1]

PERSISTENCE LENGTH OF POLYELECTROLYTE CHAINS [J].