Mesoporous bioactive glasses: Mechanical reinforcement by means of a biomimetic process

被引：37

作者：

Arcos, D. ^{[1
]}

Vila, M. ^{[1
]}

Lopez-Noriega, A. ^{[1
]}

Rossignol, F. ^{[2
]}

Champion, E. ^{[2
]}

Oliveira, F. J. ^{[3
]}

Vallet-Regi, M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dpto Quim Inorgan & Bioinorgan, Fac Farm, Networking Res Ctr Bioengn Biomat & Nanomed CIBER, E-28040 Madrid, Spain

[2] SPCTS UMR CNRS 6638, Ctr Europeen Ceram, Limoges, France

[3] Univ Aveiro, Dept Engn Ceram & Vidro, CICECO, Aveiro, Portugal

来源：

ACTA BIOMATERIALIA | 2011年 / 7卷 / 07期

关键词：

Mesoporous materials; Bioactive glasses; Mechanical properties; Scaffolds; Biomimetism; BONE TISSUE REGENERATION; IN-VITRO BIOACTIVITY; MEDICAL APPLICATIONS; DRUG-DELIVERY; SCAFFOLDS; BIOMATERIALS; POWDERS; DESIGN;

D O I：

10.1016/j.actbio.2011.02.012

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Mesoporous bioactive glasses (MBGs) constitute a new family of bioceramics with the fastest in vitro bioactivity studied so far. In this work, pieces with the composition 85SiO(2)-10CaO-5P(2)O(5) (mol.%) were prepared as MBGs and also by the conventional sol-gel method. After in vitro tests in simulated body fluid, the MBG pieces exhibited compression resistance twice as great than before, whereas conventional sol-gel glasses showed similar values. Scanning and transmission electron microscopy demonstrate the development of an apatite-like phase not only on the external surface, but also on the grains located within the MBGs pieces. In contrast, conventional sol-gel glasses only developed an apatite-like phase on the external surface. This work presents for the first time a new property of MBGs: the mechanical reinforcement of a bioactive glass through a biomimetic process. This ability is explained in terms of the outstanding bioactive behavior and the three-dimensional mesoporous structure that is exclusive for this bioceramics family. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：2952 / 2959

页数：8

共 42 条

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