Co-evolution and co-adaptation in protein networks

被引:39
作者
Juan, David [1 ]
Pazos, Florencio [2 ]
Valencia, Alfonso [1 ]
机构
[1] Spanish Nat Canc Res Ctr, Struct Bioinformat Grp, CNIO, Madrid 28029, Spain
[2] CNB CSIC, Natl Biotechnol Ctr, Computat Syst Biol Grp, Madrid 28049, Spain
关键词
co-evolution; co-adaptation; protein interaction; mirrortree;
D O I
10.1016/j.febslet.2008.02.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Interacting or functionally related proteins have been repeatedly shown to have similar phylogenetie trees. Two main hypotheses have been proposed to explain this fact. One involves compensatory changes between the two protein families (co-adaptation). The other states that the tree similarity may be an indirect consequence of the involvement of the two proteins in similar cellular process, which in turn would be reflected by similar evolutionary pressure on the corresponding sequences. There are published data supporting both propositions, and currently the available information is compatible with both hypotheses being true, in an scenario in which both sets of forces are shaping the tree similarity at different levels. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1225 / 1230
页数:6
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