Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

被引：30

作者：

Andersson, Ulrika ^{[1
]}

Dey, Estera S. ^{[2
]}

Holm, Cecilia ^{[1
]}

Degerman, Eva ^{[1
]}

机构：

[1] Lund Univ, Dept Expt Med Sci, Lund, Sweden

[2] Lund Univ, Dept Pure & Appl Biochem, Lund, Sweden

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2011年 / 55卷

关键词：

Adipose tissue; Alkylresorcinols; Lipolysis; Type; 2; diabetes; Whole grain; WHOLE-GRAIN WHEAT; DIETARY ALKYLRESORCINOLS; CEREAL ALKYLRESORCINOLS; RESORCINOLIC LIPIDS; ADIPOSE-TISSUE; BIOMARKERS; ABSORPTION; RATS;

D O I：

10.1002/mnfr.201100231

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.

引用

收藏

页码：S290 / S293

页数：4

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