Regulation of male fertility by the endocannabinoid system

被引：41

作者：

Battista, Natalia ^{[1
]}

Rapino, Cinzia ^{[1
]}

Di Tommaso, Monia ^{[1
]}

Bari, Monica ^{[2
]}

Pasquariello, Nicoletta ^{[1
]}

Maccarrone, Mauro ^{[1
,3
]}

机构：

[1] Univ Teramo, Dept Biomed Sci, I-64100 Teramo, Italy

[2] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00173 Rome, Italy

[3] IRCCS S Lucia Fdn, European Ctr Brain Res CERC, Rome, Italy

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 286卷 / 1-2期

关键词：

endocannabinoids; fertility; hormones; sperm cells; testis;

D O I：

10.1016/j.mce.2008.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian conception is a complex process regulated by both sexual behavior and reproductive performance. Alcohol, marijuana and tobacco are among the main factors which affect negatively fertility in women and men. Several studies have demonstrated that marijuana impairs the male copulatory activity, and that smokers of this illegal drug show reduced fertility due, for instance, to decrease in sperm concentration, defective sperm function or alteration of sperm morphology. The discovery of endocannabinoids and all components responsible for their metabolism has allowed to collect valuable information on the effects of these endogenous lipids, able to mimic the actions of delta-9-tetrahydrocannabinol (THC), in reproductive functions. The purpose of this review is to describe the actions of cannabinoids and endocannabinoids on the control of procreation and hormonal release during the fertilization process in males. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：S17 / S23

页数：7

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