Radiation-based approaches for therapy and palliation of advanced prostate cancer

被引：4

作者：

Lewis, Brian ^{[1
]}

Sartor, Oliver ^{[1
]}

机构：

[1] Tulane Canc Ctr, Dept Med, Div Hematol Oncol, New Orleans, LA USA

来源：

CURRENT OPINION IN UROLOGY | 2012年 / 22卷 / 03期

关键词：

alpha particles; bone; prostate cancer; radiation; radium-223; samarium; strontium; PAINFUL BONE METASTASES; SPINAL-CORD COMPRESSION; PHASE-III TRIAL; SKELETAL METASTASES; RADIOTHERAPY; IRRADIATION; ADJUVANT; MITOXANTRONE; MULTICENTER; PREDNISONE;

D O I：

10.1097/MOU.0b013e32835259d2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Purpose of review Randomized clinical trials of palliative radiation therapy and radiopharmaceuticals are emphasized, and new concepts in targeted alpha-emitter therapy are introduced. Recent findings Radiation therapy has a proven palliative role in the treatment of patients with advanced prostate cancer. Findings from (223)radium clinical trials emphasize the importance of alpha particles as a new therapeutic modality in patients with bone metastatic castrate-resistant prostate cancer. We introduce the concept of alpha-emitting particles from both a basic and clinical perspective in the realm of bone-targeted radiopharmaceuticals and discuss how these agents compare and contrast with conventional beta-emitting radioisotopes. The physics, radiobiology, and survival data with (223)radium are unique compared with previously used radiopharmaceuticals. Summary Targeted alpha-emitting therapies such as (223)radium have the capacity to change the way we treat patients with bone-metastatic prostate cancer.

引用

页码：183 / 189

页数：7

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