Shibire's enhancer is cancer's suppressor

被引：6

作者：

Deitcher, D ^{[1
]}

机构：

[1] Cornell Univ, Dept Neurobiol & Behav, Ithaca, NY 14853 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 11期

关键词：

D O I：

10.1016/S0166-2236(00)01927-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reliable neurotransmitter release requires an adequate pool of synaptic vesicles. These pools are maintained by the process of endocytosis. A recent paper revealed that dynamin, a GTPase essential for endocytosis, is regulated by Abnormal wing disc (Awd), a nucleoside diphosphate kinase which converts nucleoside diphosphates to nucleoside triphosphates. This finding suggests that access to GTP directly regulates endocytosis. In addition, awd is homologous to the tumor suppressor gene nm23, further suggesting that dynamin might be involved in tumorigenesis.

引用

页码：625 / 626

页数：2

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