Isolation of (-)-cyatha-3,12-diene, a common biosynthetic intermediate of cyathane diterpenoids, from an erinacine-producing basidiomycete, Hericium erinaceum, and its formation in a cell-free system

被引：48

作者：

Kenmoku, H

Kato, N

Shimada, M

Omoto, M

Mori, A

Mitsuhashi, W

Sassa, T ^{[1
]}

机构：

[1] Iwate Univ, Yamagata Univ, United Grad Sch Agr Sci, Yamagata 9978555, Japan

[2] Kyushu Univ, Inst Adv Mat Study, Fukuoka 8168580, Japan

[3] Kyushu Univ, Interdisciplinary Grad Sch Engn Sci, Fukuoka 8168580, Japan

[4] Yamagata Univ, Fac Agr, Dept Bioresources, Yamagata 9978555, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 42期

关键词：

biosynthesis; diterpene; structural elucidation; terpenes and terpenoids;

D O I：

10.1016/S0040-4039(01)01550-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Cyatha-3,12-diene. a diterpene hydrocarbon having a 5-6-7-membered tricyclic skeleton, has been isolated for the first time from an erinacine-producing basidiomycete, Hericium erinaceum YB4-6237. This hydrocarbon had been formulated by Ayer et al. as a common biosynthetic intermediate of cyathane diterpenoids. Its stereo-structure, including the absolute configuration, has been unambiguously confirmed by its semi-synthesis from erinacine P, and its cell-free conversion from all-trans-geranylgeranyl diphosphate was demonstrated. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7439 / 7442

页数：4

共 27 条

[1]

METABOLITES OF BIRDS NEST FUNGI .12. STUDIES ON THE BIOSYNTHESIS OF THE CYATHINS [J].