Changes in arterial blood pressure after single oral administration of cuttlefish (Sepia officinalis) muscle derived peptides in spontaneously hypertensive rats

被引：24

作者：

Balti, Rafik ^{[1
,2
]}

Bougatef, Ali ^{[2
]}

Guillochon, Didier ^{[1
]}

Dhulster, Pascal ^{[1
]}

Nasri, Moncef ^{[2
]}

Nedjar-Arroume, Naima ^{[1
]}

机构：

[1] Lab Proc Biol Genie Enzymat & Microbien, F-59655 Villeneuve Dascq, France

[2] Ecole Natl Ingenieurs Sfax, Lab Genie Enzymat & Microbiol, Sfax 3038, Tunisia

来源：

JOURNAL OF FUNCTIONAL FOODS | 2012年 / 4卷 / 03期

关键词：

Antihypertensive peptides; Cuttlefish muscle; Sepia officinalis; Arterial blood pressure; Spontaneously hypertensive rats; ANGIOTENSIN-CONVERTING ENZYME; LONG-TERM INTAKE; ACE-INHIBITORY PEPTIDE; FERMENTED MILK; SOUR MILK; PROTEIN HYDROLYSATE; PURIFICATION; TRIPEPTIDES; DISEASE; DESIGN;

D O I：

10.1016/j.jff.2012.03.007

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from cuttlefish (Sepia officinalis) muscle proteins hydrolysates, previously characterized as in vitro angiotensin-I-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The peptide sequences Val-Tyr-Ala-Pro, Val-Ile-Ile-Phe and Ala-His-Ser-Tyr showed a clear decrease in SBP and DBP in SHR. Met-Ala-Trp caused a significant decrease of the SBP in the SHR, but this sequence caused a slight decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. Thus, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：611 / 617

页数：7

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