Prohemorrhagic potential of dipyrone, ibuprofen, ketorolac, and aspirin:: Mechanisms associated with blood flow and erythrocyte deformability

被引:25
作者
Bozzo, J [1 ]
Escolar, G [1 ]
Hernández, MR [1 ]
Galán, AM [1 ]
Ordinas, A [1 ]
机构
[1] Hosp Clin Barcelona, Serv Hemoterapia & Hemostasia, Dept Hemotherapy & Hemostasis, E-08036 Barcelona, Spain
关键词
dipyrone; ibuprofen; ketorolac; aspirin; platelets;
D O I
10.1097/00005344-200108000-00003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dipyrone, ibuprofen, ketorolac, and aspirin were tested in a well-defined perfusion system (shear rates: 300/s, 800/s, and 1,800/s). Whole blood samples were treated with the drugs at analgesic doses and platelet interaction with damaged subendothelium was measured. All the drugs fully inhibited platelet cyclooxygenase, as assessed by classic aggregometry. Perfusion studies showed that there was a general tendency to reduce the percentage of large aggregates (thrombus; %T), to increase the percentage of adhered platelets (adhesion; %A), and to reduce the height of thrombi with respect to control. Aspirin significantly increased %A and reduced %T at all shear rates tested, whereas dipyrone had the same effect at 800/s, and ketorolac and ibuprofen at 1,800/s. In addition, aspirin significantly reduced erythrocyte deformability with respect to the other drugs. In conclusion, under our experimental conditions, aspirin showed the most remarkable effects on platelet function, closely followed by dipyrone. The effects of ketorolac were moderate, whereas ibuprofen had a minor impact on platelet function.
引用
收藏
页码:183 / 190
页数:8
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