Nucleophilic catalysis of the iodine-zinc exchange reaction: Preparation of highly functionalized diaryl zinc compounds

被引：120

作者：

Kneisel, FF ^{[1
]}

Dochnahl, M ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 08期

关键词：

copper; cross-coupling; iodine-zinc exchange; nucleophilic catalysis; palladium;

D O I：

10.1002/anie.200353316

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sensitive functional groups are tolerated in an iodine-zinc exchange reaction catalyzed by Li(acac). Aryl and heteroaryl diorganozinc compounds with keto, aldehyde, or isothiocyanate substituents can be prepared by this method (see example in scheme; acac = acetylacetone, NMP=1-methyl-2-pyrrolidinone). Such zinc reagents serve as substrates for a wide variety of coupling reactions.

引用

页码：1017 / 1021

页数：5

共 47 条

[1]

[Anonymous], ANGEW CHEM

[2] THE MECHANISM OF THE LITHIUM HALOGEN INTERCHANGE REACTION - A REVIEW OF THE LITERATURE [J].