Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer

被引：55

作者：

Jeon, Hyo Sung ^{[2
]}

Lee, Soo Young ^{[3
]}

Lee, Eun Jin ^{[2
]}

Yun, Seong Cheol ^{[4
]}

Cha, Eun Jung ^{[5
]}

Choi, Eugene ^{[4
]}

Na, Moon Jun ^{[4
]}

Park, Jae Yong ^{[6
]}

Kang, Jaeku ^{[1
]}

Son, Ji Woong ^{[3
,4
]}

机构：

[1] Konyang Univ, Coll Med, Dept Pharmacol, Taejon, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Biochem, Taegu, South Korea

[3] Konyang Univ, Myunggok Res Inst Med Sci, Taejon, South Korea

[4] Konyang Univ Hosp, Dept Internal Med, Taejon, South Korea

[5] Konyang Univ Hosp, Dept Pathol, Taejon, South Korea

[6] Kyungpook Natl Univ Hosp, Dept Internal Med, Taegu, South Korea

来源：

LUNG CANCER | 2012年 / 76卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

HDAC1; MicroRNA; Non-small cell lung cancer; I HISTONE DEACETYLASES; METASTASIS-ASSOCIATED PROTEIN-1; PROSTATE-CANCER; NEGATIVE REGULATION; EXPRESSION; CELLS; PROGNOSIS; APOPTOSIS; PLAYERS; AGENTS;

D O I：

10.1016/j.lungcan.2011.10.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Histone deacetylases (HDACs) play a crucial role in tumorigenesis. Over-expression of HDACs has been reported in lung cancer. The mechanism of highly expressed HDAC1 in lung cancer has yet not been determined. In the present study, we showed that miR-449a/b regulates HDAC1 by directly binding with the 3' untranslated region of the HDAC1. The expression of miR-449a/b was down-regulated and the expression of HDAC1 was up-regulated in primary lung cancer. The down expression of miR-449a/b might be one mechanism for over-expression of HDAC1 in lung cancer. miR-449a/b inhibited cell growth and anchorage-independent growth. Furthermore, co-treatment with miR-449a and HDAC inhibitors had a significant growth reduction compared with HDAC inhibitor mono-treatment. These results suggest that miR-449a/b may have a tumor suppressor function and might be a potential therapeutic candidate in patients with primary lung cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：171 / 176

页数：6

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