A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

被引：319

作者：

Lee, Seulki ^{[1
]}

Cha, Eui-Joon ^{[2
]}

Park, Kyeongsoon ^{[1
]}

Lee, Seung-Young ^{[1
]}

Hong, Jin-Ki ^{[2
]}

Sun, In-Cheol ^{[2
]}

Kim, Sang Yoon ^{[3
]}

Choi, Kuiwon ^{[1
]}

Kwon, Ick Chan ^{[1
]}

Kim, Kwangmeyung ^{[1
]}

Ahn, Cheol-Hee ^{[2
]}

机构：

[1] Korea Inst Sci & Technol, Ctr Biomed Res, Seoul 136791, South Korea

[2] Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 151744, South Korea

[3] Univ Ulsan, Sch Med, Asan Med Ctr, Seoul 138736, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 15期

关键词：

cancer diagnosis; drug screening; fluorescent probes; gold; imaging agents;

D O I：

10.1002/anie.200705240

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2804 / 2807

页数：4

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