Pan-drug-resistant Pseudomonas aeruginosa causing nosocomial infection at a university hospital in Taiwan

被引：54

作者：

Hsueh, PR

Tseng, SP

Teng, LJ

Ho, SW

机构：

[1] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[3] Natl Taiwan Univ, Coll Med, Sch Med Technol, Taipei 10018, Taiwan

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2005年 / 11卷 / 08期

关键词：

colistin; pan-drug resistance; Pseudomonas aeruginosa; resistance; synergism; time-kill studies;

D O I：

10.1111/j.1469-0691.2005.01196.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study evaluated the clinical and microbiological characteristics of 16 patients who were colonised or infected with 26 isolates of pan-drug-resistant Pseudomonas aeruginosa (PDRPA; intermediately-resistant or resistant to all cephalosporins, piperacillin-tazobactam, aztreonam, carbapenems, ciprofloxacin and aminoglycosides) in a university hospital during 1999-2002. All the isolates had colistin MICs <= 4 mg/L, 19 (73%) isolates had bla(VIM-3), and 25 (96%) isolates had class I integrons (intI). Time-kill studies for two PDRPA blood isolates demonstrated synergism for cefepime-amikacin after 24 h. Pulsed-field gel electrophoresis analysis of the isolates revealed a polyclonal nature (12 pulsotypes), although clonal dissemination of PDRPA isolates among these patients was also present.

引用

页码：670 / 673

页数：4

共 20 条

[1] Comparative in vitro bactericidal activity between cefepime and ceftazidime, alone and associated with amikacin, against carbapenem-resistant Pseudomonas aeruginosa strains [J].