Dendrimer-functionalized shell-crosslinked iron oxide nanoparticles for in-vivo magnetic resonance imaging of tumors

被引：252

作者：

Shi, Xiangyang ^{[1
]}

Wang, Su He ^{[1
]}

Swanson, Scott D. ^{[2
]}

Ge, Song ^{[3
]}

Cao, Zhengyi ^{[1
]}

Van Antwerp, Mary E. ^{[1
]}

Landmark, Kevin J. ^{[3
]}

Baker, James R., Jr. ^{[1
]}

机构：

[1] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Phys, Ann Arbor, MI 48109 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 09期

关键词：

D O I：

10.1002/adma.200702770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A powerful magnetic nanoprobe with folic acid (FA)-targeting ligands is fabricated by dendrimer functionalization of Fe3O4 nanoparticles (NPs) precoated with crosslinkable and biocompatible polymer multilayer shells. This magnetic probe allows for magnetic resonance imaging of FA receptor-overexpressing vitro and of an early-stage tumor model in vivo (see picture).

引用

页码：1671 / +

页数：9

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