Antimicrobial drug resistance: "Prediction is very difficult, especially about the future"

被引：56

作者：

Courvalin, P ^{[1
]}

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75015 Paris, France

来源：

EMERGING INFECTIOUS DISEASES | 2005年 / 11卷 / 10期

关键词：

D O I：

10.3201/eid1110.051014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Evolution of bacteria towards resistance to antimicrobial drugs, including multidrug resistance, is unavoidable because it represents a particular aspect of the general evolution of bacteria that is unstoppable. Therefore, the only means of dealing with this situation is to delay the emergence and subsequent dissemination of resistant bacteria or resistance genes. Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. Alternatively, resistance can result from the horizontal acquisition of foreign genetic information. The 2 phenomena are not mutually exclusive and can be associated in the emergence and more efficient spread of resistance. This review discusses the predictable future of the relationship between antimicrobial drugs and bacteria.

引用

页码：1503 / 1506

页数：4

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