Polymorphisms at the β2-adrenergic receptor gene influence Alzheimer's disease susceptibility

被引：57

作者：

Yu, Jin-Tai ^{[1
,2
]}

Tan, Lan ^{[1
,2
]}

Ou, Jiang-Rong ^{[1
,2
]}

Zhu, Jun-Xia ^{[3
]}

Liu, Kun ^{[3
]}

Song, Jing-Hui ^{[4
]}

Sun, Yan-Ping ^{[4
]}

机构：

[1] Ocean Univ China, Affiliated Hosp, Qingdao Municipal Hosp, Dept Neurol, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Coll Med, Qingdao Municipal Hosp, Affiliated Hosp,Dept Neurol, Qingdao, Shandong, Peoples R China

[3] Qingdao 8 Peoples Hosp, Qingdao, Shandong, Peoples R China

[4] Qingdao Univ, Coll Med, Affiliated Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China

来源：

BRAIN RESEARCH | 2008年 / 1210卷

关键词：

Alzheimer's disease; beta 2-adrenergic receptor; polymorphism;

D O I：

10.1016/j.brainres.2008.03.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Increasing evidence indicates that the beta 2-adrenergic receptor (beta 2-AR) may play an important role in Alzheimer's disease (AD). We investigated the effect of two polymorphisms in the beta 2-AR gene: Gly16Arg and Gln27Glu for the risk of sporadic Late Onset Alzheimer's Disease (LOAD) in 109 patients and 109 healthy controls matched for sex and age in a Han Chinese population. Results revealed that both the 16Gly allele and the 27Glu allele of the beta 2-AR gene were associated with an increased risk of LOAD (P=0.009, OR=1.652 and P=0.002, OR=2.846, respectively), and they also showed a highly significant interaction with the Apolipoprotein E gene (APOE) epsilon 4 allele (OR=4.200 and 9.441, respectively). Examination of the haplotypes identified the Gly16Glu27 haplotype to increase the risk of LOAD (P=0.004). Our results suggest that variations in the beta 2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon 4 allele to markedly increase the LOAD risk. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：216 / 222

页数：7

共 44 条

[1]

GLU-27 variant of β2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease [J].