Polymorphisms at the β2-adrenergic receptor gene influence Alzheimer's disease susceptibility

被引:57
作者
Yu, Jin-Tai [1 ,2 ]
Tan, Lan [1 ,2 ]
Ou, Jiang-Rong [1 ,2 ]
Zhu, Jun-Xia [3 ]
Liu, Kun [3 ]
Song, Jing-Hui [4 ]
Sun, Yan-Ping [4 ]
机构
[1] Ocean Univ China, Affiliated Hosp, Qingdao Municipal Hosp, Dept Neurol, Qingdao 266071, Shandong, Peoples R China
[2] Qingdao Univ, Coll Med, Qingdao Municipal Hosp, Affiliated Hosp,Dept Neurol, Qingdao, Shandong, Peoples R China
[3] Qingdao 8 Peoples Hosp, Qingdao, Shandong, Peoples R China
[4] Qingdao Univ, Coll Med, Affiliated Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China
关键词
Alzheimer's disease; beta 2-adrenergic receptor; polymorphism;
D O I
10.1016/j.brainres.2008.03.019
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Increasing evidence indicates that the beta 2-adrenergic receptor (beta 2-AR) may play an important role in Alzheimer's disease (AD). We investigated the effect of two polymorphisms in the beta 2-AR gene: Gly16Arg and Gln27Glu for the risk of sporadic Late Onset Alzheimer's Disease (LOAD) in 109 patients and 109 healthy controls matched for sex and age in a Han Chinese population. Results revealed that both the 16Gly allele and the 27Glu allele of the beta 2-AR gene were associated with an increased risk of LOAD (P=0.009, OR=1.652 and P=0.002, OR=2.846, respectively), and they also showed a highly significant interaction with the Apolipoprotein E gene (APOE) epsilon 4 allele (OR=4.200 and 9.441, respectively). Examination of the haplotypes identified the Gly16Glu27 haplotype to increase the risk of LOAD (P=0.004). Our results suggest that variations in the beta 2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon 4 allele to markedly increase the LOAD risk. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:216 / 222
页数:7
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