[18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro

被引：17

作者：

Burrows, RC

Freeman, SD

Charlop, AW

Wiseman, RW

Adamsen, TCH

Krohn, KA

Spence, AM ^{[1
]}

机构：

[1] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Radiol, Mol Imaging Res Ctr, Seattle, WA 98195 USA

[3] Michigan State Univ, Dept Physiol, Mol Imaging Res Ctr, E Lansing, MI 48824 USA

[4] Michigan State Univ, Dept Radiol, Mol Imaging Res Ctr, E Lansing, MI 48824 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2004年 / 31卷 / 01期

关键词：

Lumped Constant; Positron Emission Tomography; hexose metabolism; hexose transport; GLUT isoforms; glioma;

D O I：

10.1016/S0969-8051(02)00449-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes. (C) 2004 Elsevier Inc., All rights reserved.

引用

页码：1 / 9

页数：9

共 44 条

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