Damage site chromatin: open or closed?

被引：23

作者：

Ball, Alexander R., Jr. ^{[1
]}

Yokomori, Kyoko ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Biol Chem, Sch Med, Irvine, CA 92697 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRAND BREAKS; REMODELING FACTOR CHD4; DNA-DAMAGE; MAMMALIAN-CELLS; HETEROCHROMATIN PROTEIN-1; HOMOLOGOUS RECOMBINATION; LASER MICROIRRADIATION; IN-VIVO; REPAIR; RECRUITMENT;

D O I：

10.1016/j.ceb.2011.03.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Technical advances in recent years, such as laser microirradiation and chromatin immunoprecipitation, have led to further understanding of DNA damage responses and repair processes as they happen in vivo and have allowed us to better evaluate the activities of new factors at damage sites. Facilitated by these tools, recent studies identified the unexpected roles of heterochromatin factors in DNA damage recognition and repair, which also involves poly(ADP-ribose) polymerases (PARPs). The results suggest that chromatin at damage sites may be quite structurally dynamic during the repair process, with transient intervals of 'closed' configurations before a more 'open' arrangement that allows the repair machinery to access damaged DNA.

引用

页码：277 / 283

页数：7

共 58 条

[1] Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1 [J].

Ahel, Dragana ;

Horejsi, Zuzana ;

Wiechens, Nicola ;

Polo, Sophie E. ;

Garcia-Wilson, Elisa ;

Ahel, Ivan ;

Flynn, Helen ;

Skehel, Mark ;

West, Stephen C. ;

Jackson, Stephen P. ;

Owen-Hughes, Tom ;

Boulton, Simon J. .

SCIENCE, 2009, 325 (5945) :1240-1243

[2] Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins [J].

Ahel, Ivan ;

Ahel, Dragana ;

Matsusaka, Takahiro ;

Clark, Allison J. ;

Pines, Jonathon ;

Boulton, Simon J. ;

West, Stephen C. .

NATURE, 2008, 451 (7174) :81-U12

[3] HP1-β mobilization promotes chromatin changes that initiate the DNA damage response [J].

Ayoub, Nabieh ;

Jeyasekharan, Anand D. ;

Bernal, Juan A. ;

Venkitaraman, Ashok R. .

NATURE, 2008, 453 (7195) :682-U14

[4] Differential regulation of the cellular response to DNA double-strand breaks in G1 [J].

Barlow, Jacqueline H. ;

Lisby, Michael ;

Rothstein, Rodney .

MOLECULAR CELL, 2008, 30 (01) :73-85

[5] Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair [J].

Berkovich, Elijahu ;

Monnat, Raymond J., Jr. ;

Kastan, Michael B. .

NATURE CELL BIOLOGY, 2007, 9 (06) :683-U137

[6] Use of near infrared femtosecond lasers as sub-micron radiation microbeam for cell DNA damage and repair studies [J].

Botchway, S. W. ;

Reynolds, P. ;

Parker, A. W. ;

O'Neill, P. .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2010, 704 (1-3) :38-44

[7] Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage [J].

Bradshaw, PS ;

Stavropoulos, DJ ;

Meyn, MS .

NATURE GENETICS, 2005, 37 (02) :193-197

[8] Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].

Cao, R ;

Wang, LJ ;

Wang, HB ;

Xia, L ;

Erdjument-Bromage, H ;

Tempst, P ;

Jones, RS ;

Zhang, Y .

SCIENCE, 2002, 298 (5595) :1039-1043

[9] Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing [J].

Cao, R ;

Tsukada, Y ;

Zhang, Y .

MOLECULAR CELL, 2005, 20 (06) :845-854

[10] A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage [J].

Chou, Danny M. ;

Adamson, Britt ;

Dephoure, Noah E. ;

Tan, Xu ;

Nottke, Amanda C. ;

Hurov, Kristen E. ;

Gygi, Steven P. ;

Colaiacovo, Monica P. ;

Elledge, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (43) :18475-18480

← 1 2 3 4 5 6 →