Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene

被引：198

作者：

Lockhart, Shawn R. ^{[1
]}

Frade, Joao P. ^{[1
]}

Etienne, Kizee A. ^{[1
]}

Pfaller, Michael A. ^{[2
]}

Diekema, Daniel J. ^{[2
,3
]}

Balajee, S. Arunmozhi ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA

[2] Univ Iowa, Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA

[3] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 09期

关键词：

ITRACONAZOLE RESISTANCE; INVASIVE ASPERGILLOSIS; CROSS-RESISTANCE; REDUCED SUSCEPTIBILITY; ACQUIRED-RESISTANCE; VORICONAZOLE; MECHANISMS; EVOLUTION; MUTANTS; PATIENT;

D O I：

10.1128/AAC.00185-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.

引用

页码：4465 / 4468

页数：4

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