Assembly In Vitro of Tau Protein and its Implications in Alzheimer's Disease

被引：22

作者：

Avila, Jesus ^{[1
]}

Perez, Mar ^{[1
]}

Lucas, Jose J. ^{[1
]}

Gomez-Ramos, Alberto ^{[1
]}

Santa Maria, Ismael ^{[1
]}

Moreno, Francisco ^{[1
]}

Smith, Mark ^{[2
]}

Perry, George ^{[2
]}

Hernandez, Felix ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[2] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

来源：

CURRENT ALZHEIMER RESEARCH | 2004年 / 1卷 / 02期

关键词：

Tau; Assembly; Polyanions; Fatty acids and Derivates;

D O I：

10.2174/1567205043332207

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tau is a microtubule associated protein that is also the main component of the aberrant filaments that form aberrant structures like the neuropil threads or the neurofibrillary tangles, found in the brain of Alzheimer's disease patients. The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized.

引用

页码：97 / 101

页数：5

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