Reduced voltage-dependent Ca2+ signaling in CA1 neurons after brief ischemia in gerbils

被引:31
作者
Connor, JA [1 ]
Razani-Boroujerdi, S [1 ]
Greenwood, AC [1 ]
Cormier, RJ [1 ]
Petrozzino, JJ [1 ]
Lin, RCS [1 ]
机构
[1] Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA
关键词
D O I
10.1152/jn.1999.81.1.299
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An initial overload of intracellular Ca2+ plays a critical role in the delayed death of hippocampal CA1 neurons that die a few days after transient ischemia. Without direct evidence, the prevailing hypothesis has been that Ca2+ overload may recur until cell death. Here, we report the first measurements of intracellular Ca2+ in living CA1 neurons within brain slices prepared 1, 2, and 3 days after transient (5 min) ischemia. With no sign of ongoing Ca2+ overload, voltage-dependent Ca2+ transients were actually reduced after 2-3 days of reperfusion. Resting Ca2+ levels and recovery rate after loading were similar to neurons receiving no ischemic insult. The tetrodotoxin-insensitive Ca spike, normally generated by these neurons, was absent at 2 days postischemia, as was a large fraction of Ca2+-dependent spike train adaptation. These surprising findings may lead to a new perspective on delayed neuronal death and intervention.
引用
收藏
页码:299 / 306
页数:8
相关论文
共 70 条
[1]   ENHANCED CALCIUM-UPTAKE BY CA1 PYRAMIDAL CELL DENDRITES IN THE POSTISCHEMIC PHASE DESPITE SUBNORMAL EVOKED FIELD POTENTIALS - EXCITATORY AMINO-ACID RECEPTOR DEPENDENCY AND RELATIONSHIP TO NEURONAL DAMAGE [J].
ANDINE, P ;
JACOBSON, I ;
HAGBERG, H .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1992, 12 (05) :773-783
[2]   CALCIUM-UPTAKE EVOKED BY ELECTRICAL-STIMULATION IS ENHANCED POSTISCHEMICALLY AND PRECEDES DELAYED NEURONAL DEATH IN CA1 OF RAT HIPPOCAMPUS - INVOLEMENT OF N-METHYL-D-ASPARTATE RECEPTORS [J].
ANDINE, P ;
JACOBSON, I ;
HAGBERG, H .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) :799-807
[3]   EXCITATION-TRANSCRIPTION COUPLING MEDIATED BY ZINC INFLUX THROUGH VOLTAGE-DEPENDENT CALCIUM CHANNELS [J].
ATAR, D ;
BACKX, PH ;
APPEL, MM ;
GAO, WD ;
MARBAN, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2473-2477
[4]  
BONNEKOH P, 1992, ACTA NEUROPATHOL, V84, P400
[5]   SELECTIVE VULNERABILITY IN THE GERBIL HIPPOCAMPUS - MORPHOLOGICAL-CHANGES AFTER 5-MIN ISCHEMIA AND LONG SURVIVAL TIMES [J].
BONNEKOH, P ;
BARBIER, A ;
OSCHLIES, U ;
HOSSMANN, KA .
ACTA NEUROPATHOLOGICA, 1990, 80 (01) :18-25
[6]  
CHALMERSREDMAN RME, 1997, INT REV NEUROBIOL, V40, P1
[7]  
CHOI DW, 1995, TRENDS NEUROSCI, V18, P58
[8]  
CHOI DW, 1994, ANN NY ACAD SCI, V747, P162
[9]   SUSTAINED DENDRITIC GRADIENTS OF CA-2+ INDUCED BY EXCITATORY AMINO-ACIDS IN CA1 HIPPOCAMPAL-NEURONS [J].
CONNOR, JA ;
WADMAN, WJ ;
HOCKBERGER, PE ;
WONG, RKS .
SCIENCE, 1988, 240 (4852) :649-653
[10]  
CONNOR JA, 1996, NEUR ABSTR, V22, P1204