Liquid chromatography-tandem mass spectrometry for performing confirmatory analysis of veterinary drugs in animal-food products

被引：135

作者：

Gentili, A ^{[1
]}

Perret, D ^{[1
]}

Marchese, S ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2005年 / 24卷 / 07期

关键词：

animal food products; antibiotic; high-pressure collision cell; mass analyzer; veterinary drug;

D O I：

10.1016/j.trac.2005.02.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This review focuses on recent developments and trends in liquid chromatography coupled to mass spectrometry, with a particular emphasis on tandem mass spectrometry and the new criteria established by the European Union for performing confirmatory analysis of veterinary drugs in animal-food products. The combination of liquid chromatography and tandem mass spectrometry allows unequivocal identification of traces of antibiotics and antibacterial agents in complex biological matrices, such as honey, eggs, milk and meat. The sensitivity of the coupling is particularly useful for confirming the presence of banned substances that require limits of detection as low as possible. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：704 / 733

页数：30

共 89 条

[1] Simple and rapid screening and confirmation of tetracyclines in honey and egg by a dipstick test and LC-MS/MS [J].

Alfredsson, G ;

Branzell, C ;

Granelli, K ;

Lundström, Å .

ANALYTICA CHIMICA ACTA, 2005, 529 (1-2) :47-51

[2] Residues of antimicrobial drugs and feed additives in animal products:: regulatory aspects [J].

Anadón, A ;

Martínez-Larrañaga, MR .

LIVESTOCK PRODUCTION SCIENCE, 1999, 59 (2-3) :183-198

[3] Trends in the identification of organic residues and contaminants:: EC regulations under revision [J].

André, F ;

De Wasch, KKG ;

De Brabander, HF ;

Impens, SR ;

Stolker, LAM ;

van Ginkel, L ;

Stephany, RW ;

Schilt, R ;

Courtheyn, D ;

Bonnaire, Y ;

Fürst, P ;

Gowik, P ;

Kennedy, G ;

Kuhn, T ;

Moretain, JP ;

Sauer, M .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2001, 20 (08) :435-445

[4]

[Anonymous], 1990, OFFICIAL J L, V224, P0001

[5]

[Anonymous], 2002, Off. J. Eur. Comm, VL221, P8

[6]

[Anonymous], 1999, OFF J EUR COMMUN L, V224, P16

[7]

[Anonymous], 1996, Off. J. Eur. Communities, VL125, P10

[8]

BARCELO D, 1996, J CHROMATOGR LIB, V29

[9] Residue analysis of 15 penicillins and cephalosporins in bovine muscle, kidney and milk by liquid chromatography-tandem mass spectrometry [J].

Becker, M ;

Zittlau, E ;

Petz, M .

ANALYTICA CHIMICA ACTA, 2004, 520 (1-2) :19-32

[10] CONFIRMATORY ASSAY FOR THE SIMULTANEOUS DETECTION OF 5 PENICILLINS IN MUSCLE, KIDNEY AND MILK USING LIQUID-CHROMATOGRAPHY - ELECTROSPRAY MASS-SPECTROMETRY [J].

BLANCHFLOWER, WJ ;

HEWITT, SA ;

KENNEDY, DG .

ANALYST, 1994, 119 (12) :2595-2601

← 1 2 3 4 5 6 7 8 9 →