Fluvastatin improves arterial stiffness in patients with coronary artery disease and hyperlipidemia - A 5-year follow-up study

被引:57
作者
Hongo, Minoru [1 ]
Tsutsui, Hiroshi [2 ]
Mawatari, Eiichiro [2 ]
Hidaka, Hiroya [3 ]
Kumazaki, Setsuo [2 ]
Yazaki, Yoshikazu [2 ]
Takahashi, Masafumi [4 ]
Kinoshita, Osamu [2 ]
Ikeda, Uichi [2 ]
机构
[1] Shinshu Univ, Sch Hlth Sci, Dept Cardiovasc Med, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ, Sch Med, Dept Cardiovasc Med, Matsumoto, Nagano 3908621, Japan
[3] Shinshu Univ, Sch Hlth Sci, Dept Biomed Lab Sci, Matsumoto, Nagano 3908621, Japan
[4] Shinshu Univ, Grad Sch Med, Dept Organ Regenerat, Matsumoto, Nagano 3908621, Japan
关键词
arterial stiffness; coronary artery disease; fluvastatin; long-term follow-up;
D O I
10.1253/circj.72.722
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Background The present study was designed to test the hypothesis that fluvastatin might improve arterial stiffness, as assessed with pulse wave velocity (PWV), in patients with coronary artery disease (CAD) and hyperlipidemia over the long term. Methods and Results Ninety-three patients were randomly assigned to either fluvastatin (group A, n=50) or bezafibrate (group B, n=43) and followed for 5 years. There was no difference in the clinical findings between the 2 groups. In group A, there was a progressive reduction in the brachial-ankle PWV along with a decrease in serum low-density lipoprotein-cholesterol (LDL-C) and C-reactive protein (CRP) by 12 months after fluvastatin, and the improvement was maintained until 5 years after treatment. In group 13, despite identical lowering of the serum lipid, PWV was progressively increased. In group A, the percentage change in PWV correlated significantly with that of the serum CRP (r=0.49, p<0.001), but not with that of the serum LDL-C after treatment. Conclusions The beneficial vascular effects of fluvastatin persisted for a long period in patients with CAD and hyperlipidemia. Its anti-inflammatory action might contribute to the favorable effects on arterial stiffness.
引用
收藏
页码:722 / 728
页数:7
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