Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin

被引：6

作者：

Buchinger, B. ^{[1
,2
]}

Spitzer, S. ^{[1
,2
]}

Karlic, H. ^{[3
]}

Klaushofer, K. ^{[1
,2
]}

Varga, F. ^{[1
,2
]}

机构：

[1] Hanusch Hosp WGKK, Ludwig Boltzmann Inst Osteol, A-1140 Vienna, Austria

[2] Hanusch Hosp, AUVA Trauma Ctr Meidling, Dept Med 4, A-1140 Vienna, Austria

[3] Hanusch Hosp, Ludwig Boltzmann Inst Leukemia Res & Hematol, A-1140 Vienna, Austria

来源：

CANCER LETTERS | 2008年 / 265卷 / 01期

关键词：

osteosarcoma cells; suramin; lysyl oxidase; osteocalcin; telomerase activity;

D O I：

10.1016/j.canlet.2008.02.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is well known that suramin influences proliferation and differentiation of tumour cells. To study whether and how suramin effects osteosarcoma (OS) cells, proliferation, differentiation, LOX mRNA expression and telomerase activity (TA) was analysed in the human MG-63 and U-2 OS, and the rat UMR-106 OS cell lines. Data show that suramin inhibited proliferation in the human cell lines and upregulated alkaline phosphatase activity. TA was attenuated in the human cells while in UMR-106 it was not changed. In UMR-106 suramin had no influence on osteocalcin and LOX expression, in the human cells however, both genes were upregulated. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：45 / 54

页数：10

共 58 条

[1] Suramin blocks growth-stimulatory effects of platelet-derived growth factor on malignant fibrous histiocytomas in vitro [J].

Abdiu, A ;

Larsson, SE ;

Wasteson, Å ;

Walz, TM .

CANCER LETTERS, 1999, 146 (02) :189-194

[2] Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone [J].

Asou, Y ;

Rittling, SR ;

Yoshitake, H ;

Tsuji, K ;

Shinomiya, K ;

Nifuji, A ;

Denhardt, DT ;

Noda, M .

ENDOCRINOLOGY, 2001, 142 (03) :1325-1332

[3] INSULIN-LIKE GROWTH FACTOR-I IS AN AUTOCRINE REGULATOR OF HUMAN COLON CANCER CELL-DIFFERENTIATION AND GROWTH [J].

BAGHDIGUIAN, S ;

VERRIER, B ;

GERARD, C ;

FANTINI, J .

CANCER LETTERS, 1992, 62 (01) :23-33

[4] Hormones and growth factors regulate telomerase activity in ageing and cancer [J].

Bayne, S ;

Liu, JP .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2005, 240 (1-2) :11-22

[5]

Benini S, 2001, CLIN CANCER RES, V7, P1790

[6] REVERSION OF HUMAN PROSTATE TUMORIGENIC GROWTH BY AZATYROSINE [J].

BENOIT, RM ;

EISEMAN, J ;

JACOBS, SC ;

KYPRIANOU, N .

UROLOGY, 1995, 46 (03) :370-377

[7] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

[8] Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation [J].

Bodo, M ;

Lilli, C ;

Bellucci, C ;

Carinci, P ;

Calvitti, M ;

Pezzetti, F ;

Stabellini, G ;

Bellocchio, S ;

Balducci, C ;

Carinci, F ;

Baroni, T .

MOLECULAR MEDICINE, 2002, 8 (07) :393-404

[9] Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells [J].

Budiyanto, A ;

Bito, T ;

Kunisada, M ;

Ashida, M ;

Ichihashi, M ;

Ueda, M .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 121 (05) :1088-1094

[10] Telomerase immortalization of human myometrial cells [J].

Condon, J ;

Yin, S ;

Mayhew, B ;

Word, RA ;

Wright, WE ;

Shay, JW ;

Rainey, WE .

BIOLOGY OF REPRODUCTION, 2002, 67 (02) :506-514

← 1 2 3 4 5 6 →