Major depressive disorder: new clinical, neurobiological, and treatment perspectives

被引:689
作者
Kupfer, David J. [1 ]
Frank, Ellen [1 ]
Phillips, Mary L. [1 ]
机构
[1] Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
关键词
DEEP BRAIN-STIMULATION; STAR-ASTERISK-D; TRANSCRANIAL MAGNETIC STIMULATION; SEROTONIN REUPTAKE INHIBITORS; SEQUENCED TREATMENT ALTERNATIVES; RANDOMIZED CONTROLLED-TRIAL; GENE PROMOTER POLYMORPHISM; MOOD-REGULATING CIRCUIT; S-ADENOSYL METHIONINE; ANTIDEPRESSANT TREATMENT;
D O I
10.1016/S0140-6736(11)60602-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this Seminar we discuss developments from the past 5 years in the diagnosis, neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and medical comorbidity have been emphasised as important factors in improving the appropriate assessment and management of depression. Advances in neurobiology have also increased, and we aim to indicate genetic, molecular, and neuroimaging studies that are relevant for assessment and treatment selection of this disorder. Further studies of depression-specific psychotherapies, the continued application of antidepressants, the development of new treatment compounds, and the status of new somatic treatments are also discussed. We address two treatment-related issues: suicide risk with selective serotonin reuptake inhibitors, and the safety of antidepressants in pregnancy. Although clear advances have been made, no fully satisfactory treatments for major depression are available.
引用
收藏
页码:1045 / 1055
页数:11
相关论文
共 153 条
[1]  
Akiskal H.S., 2000, Bipolar Disorders: 100 Years After Manic-Depressive Insanity, P37
[2]   Elevated Amygdala Activity to Sad Facial Expressions: A State Marker of Bipolar but Not Unipolar Depression [J].
Almeida, Jorge R. C. ;
Versace, Amelia ;
Hassel, Stefanie ;
Kupfer, David J. ;
Phillips, Mary L. .
BIOLOGICAL PSYCHIATRY, 2010, 67 (05) :414-421
[3]   Antidepressant effect on connectivity of the mood-regulating circuit: An fMRI study [J].
Anand, A ;
Li, Y ;
Wang, Y ;
Wu, JW ;
Gao, SJ ;
Bukhari, L ;
Mathews, VP ;
Kalnin, A ;
Lowe, MJ .
NEUROPSYCHOPHARMACOLOGY, 2005, 30 (07) :1334-1344
[4]   Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: An fMRI study [J].
Anand, Amit ;
Li, Yu ;
Wang, Yang ;
Gardner, Kathryn ;
Lowe, Mark J. .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2007, 19 (03) :274-282
[5]  
[Anonymous], PUBL HLTH ADV PAR
[6]  
[Anonymous], PRACT GUID TREATM PA
[7]   Lithium's Emerging Role in the Treatment of Refractory Major Depressive Episodes: Augmentation of Antidepressants [J].
Bauer, Michael ;
Adli, Mazda ;
Bschor, Tom ;
Pilhatsch, Maximilian ;
Pfennig, Andrea ;
Sasse, Johanna ;
Schmid, Rita ;
Lewitzka, Ute .
NEUROPSYCHOBIOLOGY, 2010, 62 (01) :36-42
[8]   Association of the COMT val158met variant with antidepressant treatment response in major depression [J].
Baune, Bernhard T. ;
Hohoff, Christa ;
Berger, Klaus ;
Neumann, Anna ;
Mortense, Sunke ;
Roehrs, Tilmann ;
Deckert, Jurgen ;
Arolt, Volker ;
Domschke, Katharina .
NEUROPSYCHOPHARMACOLOGY, 2008, 33 (04) :924-932
[9]   The Interleukin 1 Beta (IL 1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depression [J].
Baune, Bernhard T. ;
Dannlowski, Udo ;
Domschke, Katharina ;
Janssen, Debbie G. A. ;
Jordan, Margaret A. ;
Ohrmann, Patricia ;
Bauer, Jochen ;
Biros, Erik ;
Arolt, Volker ;
Kugel, Harald ;
Baxter, Alan G. ;
Suslow, Thomas .
BIOLOGICAL PSYCHIATRY, 2010, 67 (06) :543-549
[10]   Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life [J].
Beesdo, Katja ;
Bittner, Antje ;
Pine, Daniel S. ;
Stein, Murray B. ;
Hoefler, Michael ;
Lieb, Roselind ;
Wittchen, Hans-Ulrich .
ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (08) :903-912