The association of thyroid function and heart valve sclerosis.: Results from a population-based study

Objectives: Thyroid dysfunction is associated with detrimental cardiovascular effects. We analyzed whether thyroid status is associated with aortic valve sclerosis (AVS) and mitral annular calcification (MAC) as markers of generalized atherosclerosis. Design: Data of 2065 subjects (923 women and 1142 men) aged >= 45 years from the Study of Health in Pomerania (SHIP) were analyzed with respect to low, medium and high TSH levels. Logistic regression models were adjusted for major confounders of atherosclerosis. Main outcome: In women, the prevalence of AVS was the highest in those with low TSH (35.1 % vs. 26.7% in medium TSH; p<0.05), while there was a higher prevalence of MAC in men with high TSH levels (9.2% vs. 5.2% in medium TSH; p<0.05). Compared with euthyroid men there was an increased adjusted odds ratio for MAC (OR 2.07; 95% CI 1.12-3.89, p<0.05), for the combination of AVS and MAC (OR 2.13; 95% CI 1,08-4.21, p<0.05) or for one of both (OR 1.47; 95% Cl 1.02-2.13, p<0.05) among men with high TSH. No such association was found in women. Conclusions: There was an association between thyroid function and valvular sclerosis. Men with high TSH values had increased odds for AVS or MAC, and the combination of both. These findings may reflect an increased atherosclerotic state in affected subjects.