Simultaneous determination of dextromethorphan HBr and bromhexine HCl in tablets by first-derivative spectrophotometry

被引：34

作者：

Tantishaiyakul, V ^{[1
]}

Poeaknapo, C ^{[1
]}

Sribun, P ^{[1
]}

Sirisuppanon, K ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Songkhla 90110, Thailand

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 17卷 / 02期

关键词：

dextromethorphan HBr; bromhexine HCl; first-derivative spectrophotometry; reversed-phase chromatography;

D O I：

10.1016/S0731-7085(97)00188-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid, simple and direct assay procedure based on first-derivative spectrophotometry, using a zero-crossing and peak-to-base measurement at 234 and 324 nm, respectively, has been developed for the specific determination of dextromethorphan HBr and bromhexine HCl in tablets. Calibration graphs were linear with the correlation coefficients of 0.9999 for both analytes. The limit of detections were 0.033 and 0.103 mu g ml(-1) for dextromethorphan HBr and bromhexine HCl, respectively. A HPLC method has been developed as the reference method. The results obtained by the first-derivative spectrophotometry were in good agreement with those found by the HPLC method. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：237 / 243

页数：7

共 12 条

[1]

[Anonymous], 1993, BRIT PHARMACOPOEIA

[2]

CAI R, 1993, ZHONGGUO YIYAO GONGY, V24, P309

[3] DETERMINATION OF IMIPENEM AND CILASTATIN SODIUM IN PRIMAXIN(R) BY FIRST-ORDER DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRY [J].