4-aminopyridine restores visual ocular motor function in upbeat nystagmus

被引：59

作者：

Glasauer, S ^{[1
]}

Kalla, R ^{[1
]}

Büttner, U ^{[1
]}

Strupp, M ^{[1
]}

Brandt, T ^{[1
]}

机构：

[1] Univ Munich, Dept Neurol, D-8000 Munich, Germany

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2005年 / 76卷 / 03期

关键词：

D O I：

10.1136/jnnp.2004.045716

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of the potassium channel blocker,4-aminopyridine (4-AP) on spontaneous upbeat nystagmus (UBN) was investigated with the search coil technique during fixation in different gaze positions and smooth pursuit in a patient before and after ingestion of 10 mg A-AP. UBN was reduced from 8.6 deg/s to 2.0 deg/s by 4-AP causing subjective relief from distressing oscillopsia, and impaired upward smooth pursuit was restored (gains: before medication 0.38; after medication 0.86). In the dark, UBN was slightly stronger and not affected by 4-AP. We propose that 4-AP improved the function of cerebellar pathways that mediate gaze holding and smooth pursuit by intensifying the excitability of cerebellar Purkinje cells.

引用

页码：451 / 453

页数：3

共 20 条

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[Anonymous], 1999, The Neurology of Eye Movements

[2]

BALOH RW, 1989, REV NEUROL-FRANCE, V145, P527

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