Communesins G and H, new alkaloids from the psychrotolerant fungus Penicillium rivulum

被引：104

作者：

Dalsgaard, PW

Blunt, JW

Munro, MHG

Frisvad, JC

Christophersen, C

机构：

[1] Univ Copenhagen, Dept Chem, Marine Chem Sect, DK-2100 Copenhagen, Denmark

[2] Univ Canterbury, Dept Chem, Christchurch, New Zealand

[3] Tech Univ Denmark, Ctr Microbial Biotechnol, BioCtr DTU, DK-2800 Lyngby, Denmark

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 02期

关键词：

D O I：

10.1021/np049646l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Communesins G (1) and H (2), two new alkaloids, have been isolated from the psychrotolerant, new species Penicillium rivulum Frisvad. The compounds were isolated by high-speed countercurrent chromatography and preparative HPLC using UV-guided fractionation. The structures were determined from 1D and 2D NMR techniques and HRESIMS. In contrast to all other known communesins, 1 and 2 were found inactive in antimicrobial, antiviral, and anticancer assays.

引用

收藏

页码：258 / 261

页数：4

相关论文

共 15 条

[1] Penicillium expansum:: Consistent production of patulin, chaetoglobosins, and other secondary metabolites in culture and their natural occurrence in fruit products [J].

Andersen, B ;

Smedsgaard, J ;

Frisvad, JC .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (08) :2421-2428

[2] Psychrophilin B and C:: Cyclic nitropeptides from the psychrotolerant fungus Penicillium rivulum [J].

Daisgaard, PW ;

Blunt, JW ;

Munro, MHG ;

Larsen, TO ;

Christophersen, C .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (11) :1950-1952

[3] Psychrophilin A and cycloaspeptide D, novel cyclic peptides from the psychrotolerant fungus Penicillium ribeum [J].

Dalsgaard, PW ;

Larsen, TO ;

Frydenvang, K ;

Christophersen, C .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (05) :878-881

[4]

Frisvad JC, 2004, STUD MYCOL, P1

[5]

Frisvad JC, 2004, STUD MYCOL, P201

[6]

FRISVAD JC, UNPUB INT J SYST EVO

[7] New insecticidal compounds, communesins C, D and E, from Penicillium expansum link MK-57 [J].

Hayashi, H ;

Matsumoto, H ;

Akiyama, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2004, 68 (03) :753-756

[8] New communesin derivatives from the fungus Penicillium sp derived from the Mediterranean sponge Axinella verrucosa [J].

Jadulco, R ;

Edrada, RA ;

Ebel, R ;

Berg, A ;

Schaumann, K ;

Wray, V ;

Steube, K ;

Proksch, P .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (01) :78-81

[9] Stereochemical determination of acyclic structures based on carbon-proton spin-coupling constants. A method of configuration analysis for natural products [J].

Matsumori, N ;

Kaneno, D ;

Murata, M ;

Nakamura, H ;

Tachibana, K .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (03) :866-876

[10] Biomimetic approach to communesin B (a.k.a. nomofungin) [J].

May, JA ;

Zeidan, RK ;

Stoltz, BM .

TETRAHEDRON LETTERS, 2003, 44 (06) :1203-1205