ROC curve analysis for biomarkers based on pooled assessments

被引:51
作者
Faraggi, D [1 ]
Reiser, B
Schisterman, EF
机构
[1] Univ Haifa, Dept Stat, IL-31999 Haifa, Israel
[2] NICHD, Div Epidemiol Stat & Prevent, NIH, Bethesda, MD USA
关键词
area under the ROC curve; gamma distribution; normal distribution; root mean square error;
D O I
10.1002/sim.1418
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Interleukin-6 is a biomarker of inflammation which has been suggested as having potential discriminatory ability for myocardial infarction. Because of its high assaying cost it is very expensive to evaluate this marker. In order to reduce this cost we propose pooling the specimens. In this paper we examine the efficiency of ROC curve analysis, specifically the estimation of the area under the ROC curve, when dealing with pooled data. We study the effect of pooling when there are only a fixed number of individuals available for testing and pooling is carried out to save on the number of assays. Alternatively we examine how many pooled assays of size g are necessary to provide essentially the same information as N individual assays. We measure loss of information by means of the change in root mean square error of the estimate of the area under the ROC curve and study the extent of this loss via a simulation study. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:2515 / 2527
页数:13
相关论文
共 27 条
[1]   AREA ABOVE ORDINAL DOMINANCE GRAPH AND AREA BELOW RECEIVER OPERATING CHARACTERISTIC GRAPH [J].
BAMBER, D .
JOURNAL OF MATHEMATICAL PSYCHOLOGY, 1975, 12 (04) :387-415
[2]   Association mapping of disease loci, by use of a pooled DNA genomic screen [J].
Barcellos, LF ;
Klitz, W ;
Field, LL ;
Tobias, R ;
Bowcock, AM ;
Wilson, R ;
Nelson, MP ;
Nagatomi, J ;
Thomson, G .
AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (03) :734-747
[3]  
Chilton R J, 2001, J Am Osteopath Assoc, V101, pS1
[4]   Receiver operating characteristic studies and measurement errors [J].
Coffin, M ;
Sukhatme, S .
BIOMETRICS, 1997, 53 (03) :823-837
[5]  
COFFIN M, 1995, LIFETIME DATA MODELS, P71
[6]  
CONSTANTINE K, 1986, COMMUN STAT SIMULAT, V15, P365, DOI 10.1080/03610918608812513
[7]   Estimation of the area under the ROC curve [J].
Faraggi, D ;
Reiser, B .
STATISTICS IN MEDICINE, 2002, 21 (20) :3093-3106
[8]  
Faraggi D, 2000, STAT MED, V19, P61, DOI 10.1002/(SICI)1097-0258(20000115)19:1<61::AID-SIM297>3.3.CO
[9]  
2-1
[10]   ESTIMATING PREVALENCE BY GROUP-TESTING USING GENERALIZED LINEAR-MODELS [J].
FARRINGTON, CP .
STATISTICS IN MEDICINE, 1992, 11 (12) :1591-1597