Two New Resorcinol Derivatives with Strong Cytotoxicity from the Roots of Ardisia brevicaulis DIELS

被引：21

作者：

Bao, Li ^{[3
]}

Wang, Manyuan ^{[2
]}

Zhao, Feng ^{[1
]}

Zhao, Yisong ^{[2
]}

Liu, Hongwei ^{[3
]}

机构：

[1] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

[2] Capital Univ Med Sci, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, Key Lab Systemat Mycol & Lichenol, Beijing 100080, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 12期

关键词：

Ardisia brevicaulis; Cytotoxic activity; Resorcinol derivatives;

D O I：

10.1002/cbdv.200900349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Two new resorcinol derivatives, 4-hydroxy-2-methoxy-6-[(8Z)-pentadec-8-en-1-yl]phenyl acetate (1) and 4-hydroxy-2-methoxy-6-pentadecylphenyl acetate (2), together with known compounds ardisiphenol D (3), 5-tridecylresorcinol (4), 5-pentadecylresorcinol (5), 5-[(8Z)-pentadec-8-en-1-yl]resorcinol (6), belamcandaquinones C and D (7 and 8, resp.), ardisicrenoside A, ardisiacrispin B, (22E)-24-ethyl-5 alpha-cholesta-7,22-dien-3-one, and (22E)-24-ethyl-5 alpha-cholesta-7,22-dien-3 beta-ol were isolated from the MeOH extract of the roots of Ardisia brevicaulis DIELs. Their structures were determined by spectroscopic analysis including ESI- and EI-MS, and NMR data. Cytotoxicities of 1-4 against cell lines A549, MCF-7, and PANC-1 were tested in vitro by the MTT (= 3-(4,5-dimethylthiazol 2 yl)-2,5-diphenyl-2H-tetrazolium bromide) method. Compounds 1-4 showed cytotoxic activity against all cell lines stronger than that of cisplatin against A549.

引用

页码：2901 / 2907

页数：7

共 20 条

[1]

Induction of apoptosis on human hepatocarcinoma cell lines by an alkyl resorcinol isolated from Lithraea molleoides [J].