The role of Rel/NF-κB transcription factors in B lymphocyte survival

被引：54

作者：

Gerondakis, S ^{[1
]}

Strasser, A ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Mol Genet Canc Div, Melbourne, Vic 3050, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 03期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

cells; NF-kappa B; apoptosis; bcl-2;

D O I：

10.1016/S1044-5323(03)00036-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among the transcriptional mediators of the various signal transduction pathways that have been shown to regulate lymphocyte apoptosis, Rel/NF-kappaB transcription factors have emerged as key regulators of B cell survival during their differentiation and in their activation by antigens or mitogens. The aim of this review is to bring together recent findings on Rel/NF-kappaB regulation of B cell survival and to present an intearated model of how these transcription factors control apoptosis in a signal and differentiation-stage specific manner. In addition to providing a contemporary view of Rel/NF-kappaB regulated B cell survival, the model described here is aimed to serve as a paradigm for how Rel/NF-kappaB family members control survival in different cell types during differentiation and in response to the plethora of signals that impinge on this master transcriptional regulatory pathway. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：159 / 166

页数：8

共 45 条

[1] The Bcl-2 protein family: Arbiters of cell survival
Adams, JM
Cory, S
[J]. SCIENCE, 1998, 281 (5381) : 1322 - 1326
[2] The NF-kappa B and I kappa B proteins: New discoveries and insights
Baldwin, AS
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 : 649 - 683
[3] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
Bouillet, P
Metcalf, D
Huang, DCS
Tarlinton, DM
Kay, TWH
Köntgen, F
Adams, JM
Strasser, A
[J]. SCIENCE, 1999, 286 (5445) : 1735 - 1738
[4] BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Bouillet, P
Purton, JF
Godfrey, DI
Zhang, LC
Coultas, L
Puthalakath, H
Pellegrini, M
Cory, S
Adams, JM
Strasser, A
[J]. NATURE, 2002, 415 (6874) : 922 - 926
[5] Nuclear factor κB is required for the development of marginal zone B lymphocytes
Cariappa, A
Liou, HC
Horwitz, BH
Pillai, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (08) : 1175 - 1182
[6] BCL-2 FAMILY: Regulators of cell death
Chao, DT
Korsmeyer, SJ
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 : 395 - 419
[7] BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Claudio, E
Brown, K
Park, S
Wang, HS
Siebenlist, U
[J]. NATURE IMMUNOLOGY, 2002, 3 (10) : 958 - 965
[8] The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways
Dejardin, E
Droin, NM
Delhase, M
Haas, E
Cao, YX
Makris, C
Li, ZW
Karin, M
Ware, CF
Green, DR
[J]. IMMUNITY, 2002, 17 (04) : 525 - 535
[9] Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
Franzoso, G
Carlson, L
Poljak, L
Shores, EW
Epstein, S
Leonardi, A
Grinberg, A
Tran, T
Scharton-Kersten, T
Anver, M
Love, P
Brown, K
Siebenlist, U
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) : 147 - 159
[10] Requirement for NF-κB in osteoclast and B-cell development
Franzoso, G
Carlson, L
Xing, LP
Poljak, L
Shores, EW
Brown, KD
Leonardi, A
Tran, T
Boyce, BF
Siebenlist, U
[J]. GENES & DEVELOPMENT, 1997, 11 (24) : 3482 - 3496

← 1 2 3 4 5 →