Safety and efficacy of tacrolimus rescue therapy in 55 kidney transplant patients treated with cyclosporine

被引：8

作者：

Urbizu, JM ^{[1
]}

Zárraga, S ^{[1
]}

Gómez-Ullate, P ^{[1
]}

Amenábar, JJ ^{[1
]}

Gaínza, FI ^{[1
]}

Lampreabe, I ^{[1
]}

Virto, J ^{[1
]}

Orbe, J ^{[1
]}

机构：

[1] Hosp Cruces, Serv Nephrol, Baracaldo, Bizkaia, Spain

来源：

TRANSPLANTATION PROCEEDINGS | 2003年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0041-1345(03)00610-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

To evaluate the efficacy and safety of conversion from cyclosporine to tacrolimus, we analyzed 55 kidney transplant patients who were converted due to cosmetic reasons in 42 patients, acute rejection in 2 patients, and other causes in 11 patients. At the doses and levels used, the development of diabetes mellitus was minimized. Disappearance of cosmetic side-effects and improvement of cardiovascular risk factors, together with conservation of renal function, encourage us to use tacrolimus as an efficacious and safe immunosuppressive therapy.

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页码：1704 / 1705

页数：2

相关论文

共 9 条

[1]

Randomized trial of tacrolimus plus mycophenolate mofetil or azathioprine versus cyclosporine oral solution (modified) plus mycophenolate mofetil after cadaveric kidney transplantation: Results at 2 years [J].

Ahsan, N ;

Johnson, C ;

Gonwa, T ;

Halloran, P ;

Stegall, M ;

Hardy, M ;

Metzger, R ;

Shield, C ;

Rocher, L ;

Scandling, J ;

Sorensen, J ;

Mulloy, L ;

Light, J ;

Corwin, C ;

Danovitch, G ;

Wachs, M ;

VanVeldhuisen, P ;

Salm, K ;

Tolzman, D ;

Fitzsimmons, WE .

TRANSPLANTATION, 2001, 72 (02) :245-250

[2]

Single-center experience with tacrolimus versus cyclosporine-Neoral in renal transplant recipients [J].

Boots, JMM ;

van Duijnhoven, EM ;

Christiaans, MHL ;

Nieman, FHM ;

van Suylen, RJ ;

van Hooff, JP .

TRANSPLANT INTERNATIONAL, 2001, 14 (06) :370-383

[3]

Indications, results, and complications of tacrolimus conversion in pediatric renal transplantation [J].

Flynn, JT ;

Bunchman, TE ;

Sherbotie, JR .

PEDIATRIC TRANSPLANTATION, 2001, 5 (06) :439-446

[4]

Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus [J].

Hernández, G ;

Arriba, L ;

Lucas, M ;

de Andrés, A .

JOURNAL OF PERIODONTOLOGY, 2000, 71 (10) :1630-1636

[5]

Kohnle M, 2000, Transpl Int, V13 Suppl 1, pS345, DOI 10.1007/s001470050358

[6]

Koomans HA, 2001, TRANSPLANTATION, V72, pS9

[7]

Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study [J].

Margreiter, R .

LANCET, 2002, 359 (9308) :741-746

[8]

Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression [J].

Shield, CF ;

McGrath, MM ;

Goss, TF .

TRANSPLANTATION, 1997, 64 (12) :1738-1743

[9]

A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: Evidence for improved allograft survival at five years [J].

Vicenti, F ;

Jensik, SC ;

Filo, RS ;

Miller, J ;

Pirsch, J .

TRANSPLANTATION, 2002, 73 (05) :775-782