Evidence of involvement of the mannose receptor in adhesion of Borrelia burgdorferi to monocyte/macrophages

被引：23

作者：

Cinco, M ^{[1
]}

Cini, B

Murgia, R

Presani, G

Prodan, M

Perticarari, S

机构：

[1] Univ Trieste, Dipartimento Sci Biomed, I-34127 Trieste, Italy

[2] IRCCS, Lab Anal Clin, Trieste, Italy

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 04期

关键词：

D O I：

10.1128/IAI.69.4.2743-2747.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mannose receptor (MR) plays an important role in the recognition of some pathogens in nonopsonic phagocytosis and in antigen presentation to T cells. We found that Borrelia burgdorferi, the agent of Lyme borreliosis, adheres to monocyte-derived macrophages and to rat MR-transfected cells but not to untransfected cells. Antibodies to MR and sugars such as mannose, mannan, fucose, and some lectins significantly lowered the adhesion, confirming participation of the MR in the binding.

引用

页码：2743 / 2747

页数：5

共 28 条

[1] The lipid component of lipoproteins from Borrelia burgdorferi:: Structural analysis, antigenicity, and presentation via human dendritic cells [J].

Beermann, C ;

Lochnit, G ;

Geyer, R ;

Groscurth, P ;

Filgueira, L .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 267 (03) :897-905

[2] Lipoproteins from Borrelia burgdorferi applied in liposomes and presented by dendritic cells induce CD8+ T-lymphocytes in vitro [J].

Beermann, C ;

Wunderli-Allenspach, H ;

Groscurth, P ;

Filgueira, L .

CELLULAR IMMUNOLOGY, 2000, 201 (02) :124-131

[3] SIMULTANEOUS MEASUREMENT BY FLOW-CYTOMETRY OF PHAGOCYTOSIS AND METABOLIC BURST INDUCED IN PHAGOCYTIC-CELLS IN WHOLE-BLOOD BY BORRELIA-BURGDORFERI [J].

CINCO, M ;

MURGIA, R ;

PERTICARARI, S ;

PRESANI, G .

FEMS MICROBIOLOGY LETTERS, 1994, 122 (1-2) :187-193

[4] Integrin CR3 mediates the binding of nonspecifically opsonized Borrelia burgdorferi to human phagocytes and mammalian cells [J].

Cinco, M ;

Murgia, R ;

Presani, G ;

Perticarari, S .

INFECTION AND IMMUNITY, 1997, 65 (11) :4784-4789

[5]

Cinco M, 1998, WIEN KLIN WOCHENSCHR, V110, P866

[6]

Cinco M, 2000, J MOL MICROB BIOTECH, V2, P575

[7] Integrins αvβ3 and α5β1 mediate attachment of Lyme disease spirochetes to human cells [J].

Coburn, J ;

Magoun, L ;

Bodary, SC ;

Leong, JM .

INFECTION AND IMMUNITY, 1998, 66 (05) :1946-1952

[8] DIVERSE LYME-DISEASE SPIROCHETES BIND INTEGRIN ALPHA(IIB)BETA(3) ON HUMAN PLATELETS [J].

COBURN, J ;

BARTHOLD, SW ;

LEONG, JM .

INFECTION AND IMMUNITY, 1994, 62 (12) :5559-5567

[9]

Condaminet B, 1998, EUR J IMMUNOL, V28, P3541, DOI 10.1002/(SICI)1521-4141(199811)28:11<3541::AID-IMMU3541>3.3.CO

[10]

2-W

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