Novel magnetic antimicrobial nanocomposites for bone tissue engineering applications

被引：21

作者：

Bhowmick, Arundhati ^{[1
]}

Saha, Arijit ^{[2
]}

Pramanik, Nilkamal ^{[1
]}

Banerjee, Subhash ^{[2
]}

Das, Manas ^{[3
]}

Kundu, Patit Paban ^{[1
]}

机构：

[1] Univ Calcutta, Dept Polymer Sci & Technol, Kolkata 700009, India

[2] Guru Ghasidas Vishwavidyalaya, Dept Chem, Bilaspur 495009, Chhattisgarh, India

[3] Univ Calcutta, Dept Chem Engn, Kolkata 700009, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 32期

关键词：

PULSED ELECTROMAGNETIC-FIELDS; IRON-OXIDE NANOPARTICLES; IN-VITRO; SILVER NANOPARTICLES; SCAFFOLDS; CHITOSAN; DIFFERENTIATION; HYPERTHERMIA; ADHESION; CALCIUM;

D O I：

10.1039/c5ra02413g

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

In the present study, we demonstrate the fabrication of novel bone-like magnetic nanocomposites by the blending of chitosan, polymethylmethacrylate-co-2-hydroxyethylmethacrylate, and nanohydroxyapatite- Fe3O4. The hybrid nanomaterials were thoroughly characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction and field emission scanning electron microscopy. The magnetic nanocomposites exhibited excellent mechanical properties (e.g. tensile strength, Young's modulus and stiffness) and antimicrobial activities. Hemolysis assays indicated that blood compatibility of the polymer sample is significant. Water uptake ability of the nanocomposite materials was found to increase with increasing the proportion of PMMA-co-PHEMA. In addition, the superparamagnetic nature of the nanocomposite was observed which makes these materials suitable for magnetic therapy.

引用

页码：25437 / 25445

页数：9

共 56 条

[1]

Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: An in vitro study [J].