Profluorescent Nitroxides as Sensitive Probes of Oxidative Change and Free Radical Reactions

被引：99

作者：

Blinco, James P. ^{[1
]}

Fairfull-Smith, Kathryn E. ^{[2
]}

Morrow, Benjamin J. ^{[2
]}

Bottle, Steven E.

机构：

[1] KIT, Inst Tech Chem & Polymerchem, D-76128 Karlsruhe, Germany

[2] Queensland Univ Technol, Ctr Excellence Free Radical Chem & Biotechnol, Australian Res Council, Brisbane, Qld 4001, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2011年 / 64卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

CARBON-CENTERED RADICALS; STABLE FREE-RADICALS; NITRIC-OXIDE; FLUORESCENCE DETECTION; PARALLAX ANALYSIS; CIGARETTE-SMOKE; SPIN-LABEL; SPECTRAL CHARACTERISTICS; PHOTOCHEMICAL STABILITY; ISOINDOLINE NITROXIDES;

D O I：

10.1071/CH10442

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper presents a review on the use of tethered nitroxide-fluorophore molecules as probes of oxidative change and free radical generation and reaction. The proximity of the nitroxide free radical to the fluorophore suppresses the normal fluorescence emission process. Nitroxide free radical scavenging, metabolism or redox chemistry return the system to its natural fluorescent state and so these tethered nitroxide-fluorophore molecules are described as being profluorescent. A survey of profluorescent nitroxides found in the literature is provided as well as background on the mechanism of action and applications of these compounds as fluorometric probes within the fields of biological, materials and environmental sciences.

引用

页码：373 / 389

页数：17

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