Lipase-catalyzed kinetic resolution of 2-acyloxy-2-(pentafluorophenyl)acetonitrile

被引：25

作者：

Sakai, T ^{[1
]}

Miki, Y ^{[1
]}

Nakatani, M ^{[1
]}

Ema, T ^{[1
]}

Uneyama, K ^{[1
]}

Utaka, M ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Appl Chem, Okayama 7008530, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 29期

关键词：

cyanohydrins; enzymes and enzyme reactions; resolution; X-ray crystal structures;

D O I：

10.1016/S0040-4039(98)01029-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lipase-catalyzed kinetic resolution of (+/-)-2-acyloxy-2-(pentafluorophenyl)acetonitrile (+/-)-1 gave optically active cyanohydrin (S)-2 and its antipodal ester (R)-1 (E = 211), the former of which was transformed (TBSOTf, DMAP) into its TBS-ether (S)-3, a new fluorinated chiral building block, and into naproxen ester 4 for X-ray analysis to determine the absolute configuration. (C) 1998 Published by Elsevier Science Ltd. Ail rights reserved.

引用

页码：5233 / 5236

页数：4

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