Familial forms broaden the horizons for primary aldosteronism

被引：25

作者：

Gordon, RD ^{[1
]}

Stowasser, M ^{[1
]}

机构：

[1] Univ Queensland, Greenslopes Hosp, Hypertens Unit, Dept Med, Brisbane, Qld 4120, Australia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1998年 / 9卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1043-2760(98)00058-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The identification of familial forms of primary aldosteronism (PAL) has led to its detection in relatives of affected patients not suspected previously of having PAL. Many ave normokalemic and some ave even normotensive. This broadens the spectrum of PAL, permitting the study of its evolution and of intervention with specific therapy when hypertension develops. The genetic basis of one form involves steroid biosynthetic enzymes and the other form predisposes to hyperplasia and benign neoplasia.

引用

页码：220 / 227

页数：8

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