In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm

被引：44

作者：

Guo, Chun Xian ^{[1
,2
]}

Zheng, Xin Ting ^{[1
,2
]}

Ng, Shu Rui ^{[1
,2
]}

Lai, Yicheng ^{[3
]}

Lei, Yu ^{[4
]}

Li, Chang Ming ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Ctr Adv Bionanosyst, Singapore 637457, Singapore

[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore

[3] ASTAR, Data Storage Inst, Singapore 117608, Singapore

[4] Univ Connecticut, Dept Chem Mat & Biomol Engn, Storrs, CT 06269 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 09期

关键词：

GLASSY-CARBON ELECTRODE; DIRECT ELECTROCHEMISTRY; HYDROGEN-PEROXIDE; GOLD NANOPARTICLES; BIOSENSOR; PLATFORM; NANOCOMPOSITE; HEMOGLOBIN; NANOTUBES; GROWTH;

D O I：

10.1039/c0cc04542j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To overcome shortcomings of the ex situ approaches, in situ detection using H2O2 molecules to diagnose ischemia through enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm is demonstrated and it is discovered that the extracellular H2O2 molecule released per ischemic cell is 2.7-times of that of a normal cell.

引用

页码：2652 / 2654

页数：3

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