Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone-binding globulin and androgen receptor polymorphisms

被引：10

作者：

Diaz, Marta ^{[1
,2
]}

Lopez-Bermejo, Abel ^{[3
]}

Petry, Clive J. ^{[4
]}

de Zegher, Francis ^{[5
]}

Ibanez, Lourdes ^{[1
,2
]}

机构：

[1] Univ Barcelona, Endocrinol Unit, Hosp St Joan de Deu, Barcelona 08950, Spain

[2] ISCIII, CIBER Diabet & Enfermedades Metab Asociadas, Madrid, Spain

[3] Dr Josep Trueta Hosp, Dept Pediat, Girona, Spain

[4] Univ Cambridge, Dept Paediat, Cambridge, England

[5] Univ Leuven, Dept Woman & Child, Leuven, Belgium

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 07期

关键词：

Sex hormone-binding globulin; androgen receptor; polymorphism; insulin sensitivity; metformin; pharmacogenomics; POLYCYSTIC-OVARY-SYNDROME; CAG REPEAT POLYMORPHISM; SHBG GENE; PRECOCIOUS PUBARCHE; WOMEN; HYPERANDROGENISM; INSULIN; MEN; HYPERINSULINISM; SENSITIZATION;

D O I：

10.1016/j.fertnstert.2010.06.083

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

We studied the effects of the SHBG (TAAAA)(n) and androgen receptor gene [AR] (CAG)(n) allele length on endocrine-metabolic features and body composition (by dual-energy X-ray absorptiometry) before and after 1 year on metformin (850 mg/d) in 70 girls with polycystic ovary syndrome after precocious pubarche; allele lengths were assessed by polymerase chain reaction in both patients and in population control subjects (n = 107). Longer SHBG (TAAAA)(n) alleles (>8 repeats) were associated with more improvement of the lipid profile after 1 year on metformin, whereas longer AR (CAG)(n) alleles were related to more normalization of the androgen and lipid levels after therapy; longer alleles in both genes had an additive effect on the beneficial changes of SHBG, T, and lipids after metformin. (Fertil Steril (R) 2010;94:2800-3. (C) 2010 by American Society for Reproductive Medicine.)

引用

页码：2800 / U1700

页数：5

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