Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers

被引：13

作者：

Ribeiro, Marcelo Lima ^{[1
]}

Arcari, Demetrius Paiva ^{[1
]}

Squassoni, Aline Candido ^{[1
]}

Pedrazzoli, Jose, Jr. ^{[1
]}

机构：

[1] Univ Sao Francisco, Unit Integrad Farmacol Gastroenterol, Braganca Paulista, SP, Brazil

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2007年 / 128卷 / 10期

关键词：

antioxidant; multivitamin; comet assay;

D O I：

10.1016/j.mad.2007.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of this study was to evaluate the effect of a mixture of vitamins and minerals on oxidative DNA damage and the resistance of DNA to H2O2-induced DNA strand breaks in lymphocytes from 80 elderly volunteers ex vivo by means of Comet assay. The intervention with vitamin complex decreased significantly the levels of DNA damage. Our results demonstrate that the vitamin complex was able to decrease H2O2-induced DNA breakage. Our data suggest that the consumption of some vitamins may reduce the effects of oxidative DNA damage and may be useful for attaining healthy aging. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：577 / 580

页数：4

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