Central nervous system serotonin function and cardiovascular responses to stress

被引:107
作者
Williams, RB
Marchuk, DA
Gadde, KM
Barefoot, JC
Grichnik, K
Helms, MJ
Kuhn, CM
Lewis, JG
Schanberg, SM
Stafford-Smith, M
Suarez, EC
Clary, GL
Svenson, IK
Siegler, IC
机构
[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA
来源
PSYCHOSOMATIC MEDICINE | 2001年 / 63卷 / 02期
关键词
serotonin; brain; cardiovascular reactivity; stress; genes (serotonin transporter promoter polymorphism);
D O I
10.1097/00006842-200103000-00016
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The objective of this study was to evaluate the impact of indices of central nervous system (CNS) serotonin function on cardiovascular reactivity to mental stress. Methods: Lumbar puncture was performed on 54 healthy volunteers to obtain cerebrospinal fluid (CSF) for determination of 5-hydroxyindoleacetic acid (5HIAA) levels. Genotypes were determined with respect to a functional polymorphism of the serotonin transporter gene promoter region (5HTTLPR). Subjects then underwent mental stress testing. Results: Persons with one or two long [I) 5HTTLPR alleles had CSF levels of the major serotonin metabolite, 5HIAA, that were 50% higher than those of persons with the s/s 5HTTLPR genotype. Persons with one or two 1 alleles or higher CSF 5HIAA levels also exhibited greater blood pressure and heart rate responses to a mental stress protocol. Conclusions: These findings suggest the 5HTTLPR polymorphism affects CNS serotonin function, and they are consistent with the general hypothesis that CNS serotonin function is involved in the regulation of potentially health-damaging biobehavioral characteristics. In particular, the I allele could contribute, through its association with increased cardiovascular reactivity to stress, to increased risk of cardiovascular disease.
引用
收藏
页码:300 / 305
页数:6
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