MMR and autism: further evidence against a causal association

被引:112
作者
Farrington, CP
Miller, E
Taylor, B
机构
[1] Open Univ, Dept Stat, Milton Keynes MK7 6AA, Bucks, England
[2] Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Immunisat Div, London NW9 5EQ, England
[3] UCL, Ctr Community Child Hlth, Royal Free & Univ Coll Med Sch, London NW3 2QG, England
关键词
autism; MMR; adverse events;
D O I
10.1016/S0264-410X(01)00097-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The hypothesis that MMR vaccines cause autism was first raised by reports of cases in which developmental regression occurred soon after MMR vaccination. A previous study found no evidence to support this hypothesis. It has recently been suggested that MMR vaccine might cause autism, but that the induction interval need not be short. The data from the earlier study were reanalysed to test this second hypothesis. Our results do not support this hypothesis. and provide further evidence against a causal association between MMR vaccination and autism. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3632 / 3635
页数:4
相关论文
共 8 条
  • [1] [Anonymous], 1998, British Medical Journal, DOI DOI 10.1136/BMJ.316.7130.561
  • [2] Farrington CP, 1996, AM J EPIDEMIOL, V143, P1165
  • [3] RELATIVE INCIDENCE ESTIMATION FROM CASE SERIES FOR VACCINE SAFETY EVALUATION
    FARRINGTON, CP
    [J]. BIOMETRICS, 1995, 51 (01) : 228 - 235
  • [4] Roger JH, 2000, LANCET, V356, P160, DOI 10.1016/S0140-6736(05)73169-X
  • [5] Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association
    Taylor, B
    Miller, E
    Farrington, CP
    Petropoulos, MC
    Favot-Mayaud, I
    Li, J
    Waight, PA
    [J]. LANCET, 1999, 353 (9169) : 2026 - 2029
  • [6] Response to the MMR question
    Taylor, B
    Miller, E
    Farrington, CP
    [J]. LANCET, 2000, 356 (9237) : 1273 - 1273
  • [7] RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children (Retracted article. See vol 375, pg 445, 2010)
    Wakefield, AJ
    Murch, SH
    Anthony, A
    Linnell, J
    Casson, DM
    Malik, M
    Berelowitz, M
    Dhillon, AP
    Thomson, MA
    Harvey, P
    Valentine, A
    Davies, SE
    Walker-Smith, JA
    [J]. LANCET, 1998, 351 (9103) : 637 - 641
  • [8] Wakefield AJ, 2000, 106 C US HOUS REPR C