Medicinal flowers.: III.: Marigold.: (1):: Hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis

被引：112

作者：

Yoshikawa, M ^{[1
]}

Murakami, T ^{[1
]}

Kishi, A ^{[1
]}

Kageura, T ^{[1
]}

Matsuda, H ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 07期

关键词：

calendasponin; Calendula officinalis; marigold; hypoglycemic activity; gastroprotective activity; gastric emptying inhibitory activity;

D O I：

10.1248/cpb.49.863

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract and its 1-butanol-soluble fraction from the flowers of Calendula officinalis were found to show a hypoglycemic effect, inhibitory activity of gastric emptying, and gastroprotective effect. From the 1-butanol-soluble fraction, four new triterpene oligoglycosides, calendasaponins A, B, C, and D, were isolated, together with eight known saponins, seven known flavonol glycosides, and a known sesquiterpene glucoside, Their structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, glycosides A, B, C, D, and F, exhibited potent inhibitory effects on an increase in serum glucose Levels in glucose-loaded rats, gastric emptying in mice, and ethanol- and indomethacin-induced gastric lesions in rats. Some structure-activity relationships are discussed.

引用

页码：863 / 870

页数：8

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