Deep brain stimulation for Parkinson's disease

被引：607

作者：

Benabid, AL ^{[1
]}

机构：

[1] Univ Grenoble 1, Univ Hosp, IMSERM Preclin Neurosci U318, F-38043 Grenoble, France

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/j.conb.2003.11.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Deep brain stimulation at high frequency was first used in 1997 to replace thalamotomy in treating the characteristic tremor of Parkinson's disease, and has subsequently been applied to the pallidum and the subthalamic nucleus. The subthalamic nucleus is a key node in the functional control of motor activity in the basal ganglia. Its inhibition suppresses symptoms in animal models of Parkinson's disease, and high frequency chronic stimulation does the same in human patients. Acute and long-term results after deep brain stimulation show a dramatic and stable improvement of a patient's clinical condition, which mimics the effects of levodopa treatment. The mechanism of action may involve a functional disruption of the abnormal neural messages associated with the disease. Long-term changes, neural plasticity and neural protection might be induced in the network. Similar effects of stimulation and lesioning have led to the extension of this technique for other targets and diseases.

引用

页码：696 / 706

页数：11

共 89 条

[1]

Abosch, A ;

Hutchison, WD ;

Saint-Cyr, JA ;

Dostrovsky, JO ;

Lozano, AM .

JOURNAL OF NEUROSURGERY, 2002, 97 (05) :1167-1172

[2]

THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375

[3]

FUNCTIONAL ARCHITECTURE OF BASAL GANGLIA CIRCUITS - NEURAL SUBSTRATES OF PARALLEL PROCESSING [J].

ALEXANDER, GE ;

CRUTCHER, MD .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :266-271

[4]

STEREOTAXIC VENTROLATERAL THALAMOTOMY - IS VENTRICULOGRAPHY NECESSARY [J].

ALTERMAN, RL ;

KALL, BA ;

COHEN, H ;

KELLY, PJ .

NEUROSURGERY, 1995, 37 (04) :717-721

[5]

Alvarez L, 2001, MOVEMENT DISORD, V16, P72, DOI 10.1002/1531-8257(200101)16:1<72::AID-MDS1019>3.0.CO

[6]

2-6

[7]

LESION OF THE SUBTHALAMIC NUCLEUS FOR THE ALLEVIATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED PARKINSONISM IN THE PRIMATE [J].

AZIZ, TZ ;

PEGGS, D ;

SAMBROOK, MA ;

CROSSMAN, AR .

MOVEMENT DISORDERS, 1991, 6 (04) :288-292

[8]

Transient acute depression induced by high-frequency deep-brain stimulation [J].

Bejjani, BP ;

Damier, P ;

Arnulf, I ;

Thivard, L ;

Bonnet, AM ;

Dormont, D ;

Cornu, P ;

Pidoux, B ;

Samson, Y ;

Agid, Y .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (19) :1476-1480

[9]

Aggressive behavior induced by intraoperative stimulation in the triangle of Sano [J].

Bejjani, BP ;

Houeto, JL ;

Hariz, M ;

Yelnik, J ;

Mesnage, V ;

Bonnet, AM ;

Pidoux, B ;

Dormont, D ;

Cornu, P ;

Agid, Y .

NEUROLOGY, 2002, 59 (09) :1425-1427

[10]

Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus and of other nuclei as a treatment for Parkinson's disease [J].

Benabid, AL ;

Benazzouz, A ;

Gao, DM ;

Hoffmann, D ;

Limousin, P ;

Koudsie, A ;

Krack, P ;

Pollak, P .

TECHNIQUES IN NEUROSURGERY, 1999, 5 (01) :5-30

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