Proton magnetic resonance spectroscopy in brain tumours:: clinical applications

被引:43
作者
Burtscher, IM [1 ]
Holtås, S [1 ]
机构
[1] Univ Lund Hosp, Dept Diagnost Radiol, S-22185 Lund, Sweden
关键词
magnetic resonance spectroscopy; brain tumours;
D O I
10.1007/s002340000427
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Parallel to the rapid development of clinical MRI, MR spectroscopy (MRS) has, after starting as an analytical tool used in chemistry and physics, evolved to a noninvasive clinical examination. Most common neuroradiological diagnostic indications for MRS are functional inborn errors, neonatal hypoxia, ischaemia, metabolic diseases, white matter and degenerative diseases, epilepsy, inflammation, infections and intracranial neoplasm. Compared to CT and MRI, well-established morphological diagnostic tools, MRS provides information on the metabolic state of brain tissue. We review the clinical impact of MRS in diagnosis of tumours and their differentiation from non-neoplastic lesions.
引用
收藏
页码:345 / 352
页数:8
相关论文
共 91 条
[1]   Focal brain lesions: Effect of single-voxel proton MR spectroscopic findings on treatment decisions [J].
Adamson, AJ ;
Rand, SD ;
Prost, RW ;
Kim, TA ;
Schultz, C ;
Haughton, VM .
RADIOLOGY, 1998, 209 (01) :73-78
[2]   Quantification of metabolites from single-voxel in vivo H-1 NMR data of normal human brain by means of time-domain data analysis [J].
AlaKorpela, M ;
Usenius, JP ;
Keisala, J ;
vandenBoogaart, A ;
Vainio, P ;
Jokisaari, J ;
Soimakallio, S ;
Kauppinen, R .
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 1995, 3 (3-4) :129-136
[3]   Prediction of posterior fossa tumor type in children by means of magnetic resonance image properties, spectroscopy, and neural networks [J].
Arle, JE ;
Morriss, C ;
Wang, ZYJ ;
Zimmerman, RA ;
Phillips, PG ;
Sutton, LN .
JOURNAL OF NEUROSURGERY, 1997, 86 (05) :755-761
[4]   QUANTITATION OF PROTON NMR-SPECTRA OF THE HUMAN BRAIN USING TISSUE WATER AS AN INTERNAL CONCENTRATION REFERENCE [J].
BARKER, PB ;
SOHER, BJ ;
BLACKBAND, SJ ;
CHATHAM, JC ;
MATHEWS, VP ;
BRYAN, RN .
NMR IN BIOMEDICINE, 1993, 6 (01) :89-94
[5]   Brain stem involvement in children with neurofibromatosis Type 1: Role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma [J].
Broniscer, A ;
Gajjar, A ;
Bhargava, R ;
Langston, JW ;
Heideman, R ;
Jones, D ;
Kun, LE ;
Taylor, J .
NEUROSURGERY, 1997, 40 (02) :331-337
[6]   PRACTICAL APPLICATIONS OF CHEMICAL-SHIFT IMAGING [J].
BROWN, TR .
NMR IN BIOMEDICINE, 1992, 5 (05) :238-243
[7]   ON THE INTERPRETATION OF PROTON NMR-SPECTRA FROM BRAIN-TUMORS INVIVO AND INVITRO [J].
BRUHN, H ;
MICHAELIS, T ;
MERBOLDT, KD ;
HANICKE, W ;
GYNGELL, ML ;
HAMBURGER, C ;
FRAHM, J .
NMR IN BIOMEDICINE, 1992, 5 (05) :253-258
[8]  
Burtscher IM, 1999, AM J NEURORADIOL, V20, P1049
[9]  
Burtscher IM, 2000, AM J NEURORADIOL, V21, P84
[10]  
Burtscher IM, 1997, ACTA RADIOL, V38, P953