Both the hippocampus and striatum are involved in consolidation of motor sequence memory

被引：346

作者：

Albouy, Genevieve ^{[1
,2
,3
,4
]}

Sterpenich, Virginie ^{[1
]}

Balteau, Evelyne ^{[1
]}

Vandewalle, Gilles ^{[1
]}

Desseilles, Martin ^{[1
]}

Dang-Vu, Thanh ^{[1
]}

Darsaud, Annabelle ^{[1
]}

Ruby, Perrine ^{[3
,4
]}

Luppi, Pierre-Herve ^{[2
,4
]}

Degueldre, Christian ^{[1
]}

Peigneux, Philippe ^{[1
]}

Luxen, Andre ^{[1
]}

Maquet, Pierre ^{[1
]}

机构：

[1] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

[2] CNRS, Inst Federatif Neurosci Lyon, Unite Mixte Rech 5167, F-69372 Lyon, France

[3] Inst Natl Sante & Rech Med, Inst Federatif Neurosci Lyon, Unite 821, F-65500 Lyon, France

[4] Univ Lyon 1, F-69622 Lyon, France

来源：

NEURON | 2008年 / 58卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2008.02.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.

引用

页码：261 / 272

页数：12

共 62 条

[1] Implicit oculomotor sequence learning in humans: Time course of offline processing [J].