Growing old with epilepsy: The neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy

被引：58

作者：

Hermann, Bruce ^{[1
,4
]}

Seidenberg, Michael ^{[2
]}

Sager, Mark ^{[3
,4
]}

Carlsson, Cynthia ^{[3
,5
]}

Gidal, Barry ^{[6
]}

Sheth, Raj ^{[1
]}

Rutecki, Paul ^{[1
,7
]}

Asthana, Sanjay ^{[3
,5
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurol, Mathews Neuropsychol Lab, Madison, WI 53792 USA

[2] Rosalind Franklin Sch Med & Sci, Dept Psychol, N Chicago, IL USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Geriatr Med, Madison, WI 53792 USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Inst, Madison, WI 53792 USA

[5] William S Middleton Mem Vet Adm Med Ctr, GRECC, Madison, WI USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Sch Pharm, Madison, WI 53792 USA

[7] William S Middleton Mem Vet Adm Med Ctr, Dept Neurol, Madison, WI USA

来源：

EPILEPSIA | 2008年 / 49卷 / 05期

关键词：

aging; cognition; chronic epilepsy; risk factors;

D O I：

10.1111/j.1528-1167.2007.01435.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of this review is to examine what is known about cognitive and brain aging in elders with chronic epilepsy. We contend that much remains to be learned about the ultimate course of cognition and brain structure in persons with chronic epilepsy and concern appears warranted. Individuals with chronic epilepsy are exposed to many risk factors demonstrated to be associated with abnormal cognitive and brain aging in the general population, with many of these risk factors present in persons with chronic epilepsy as early as midlife. We suggest that a research agenda be developed to systematically identify and treat known modifiable risk factors in order to protect and promote cognitive and brain health in aging and elder persons with chronic epilepsy.

引用

页码：731 / 740

页数：10

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