The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation

被引：20

作者：

Benz, Corinna ^{[1
]}

Mulindwa, Julius ^{[1
]}

Ouna, Benard ^{[1
]}

Clayton, Christine ^{[1
]}

机构：

[1] Zentrum Mol Biol Heidelberg, ZMBH DKFZ Alliance, D-69120 Heidelberg, Germany

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2011年 / 177卷 / 02期

关键词：

Trypanosoma; Differentiation; mRNA degradation; CCCH zinc finger; RNA binding; CCCH PROTEIN; MESSENGER-RNAS; IDENTIFICATION; CULTURE; SLENDER; FORMS;

D O I：

10.1016/j.molbiopara.2011.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, the degradation of mRNAs that have AU-rich elements in their 3'-untranslated regions is accelerated by the binding of proteins that contain two CCCH-zinc-finger-domains. Three CCCH zinc-finger proteins, TbZFP1, TbZFP2, and TbZFP3, have been shown to have roles in trypanosome differentiation. We here studied another protein, ZC3H18, which has two CCCH zinc finger domains. The ZC3H18 gene is not essential in bloodstream forms, but in an in vitro model of differentiation, depletion of ZC3H18 delayed the transformation of bloodstream-form trypanosomes to the procyclic form that grows in the Tsetse fly. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：148 / 151

页数：4

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